[Thad E Ginathom]

I don't see anyone being convinced or having their positions changed. Apart from one UK court action, I don't see any new information.

Oh no it doesn't; Oh yes it does.

I don't think we can get beyond that at this time and the conversation is just going around the circle. Maybe in the future we will. See you all back here then. Stay well

[SuperGirl_Dad]

Now its time for Covaxin to get into limelight.

ICMR distances itself from BHU study on Covaxin, calls it 'poorly designed'

"The study involved 635 adolescents and 291 adults, who received Covaxin. The participants were interviewed over phone about long-term adverse events of special interest (AESI) after one year of vaccination."

Wow

[Thad E Ginathom]

Originally Posted by SuperGirl_Dad

ICMR distances itself from BHU study on Covaxin, calls it 'poorly designed'

That, as it stands, is confusing. What was poorly designed, some study, or Covaxin?

Went to the link. It is the study that was said to be poorly designed.

Headlines are often written like this!

[Fuldagap]

This is the news that was about Covaxin. ICMR has buffed the following study aside though.

Nearly one-third of the individuals who received Bharat Biotech’s anti-Covid vaccine Covaxin reported ‘adverse events of special interest,’ or AESI, according to a one-year follow up study conducted by a team of researchers at BHU.

Nearly 50 per cent of 926 study participants in the study complained of infections during the follow-up period, predominated by viral upper respiratory tract infections.

Serious AESI, which included stroke and Guillain-Barre syndrome, were reported in one per cent of individuals, the study, which looked at long-term safety of the BBV152 vaccine in adolescents and adults, claimed.

Published in the journal Springer Nature, the study comes in the wake of UK pharmaceutical giant AstraZeneca admitting its Covid vaccine can cause rare side-effects of blood clotting and lowering of platelet count in UK court.

“Close to one third of the individuals developed AESIs. New-onset skin and subcutaneous disorders, general disorders, and nervous system disorders were the three most common disorders observed in adolescents after receiving the vaccine,” the study, conducted from January 2022 to August 2023, said.

The study involved 635 adolescents and 291 adults, who received the BBV152 vaccine. The participants were interviewed telephonically about long-term adverse events of special interest after 1 year of vaccination.

New-onset skin and subcutaneous disorders (10.5 per cent), general disorders (10.2 per cent), and nervous system disorders (4.7 per cent) were the common AESIs in adolescents.

General disorders (8.9), musculoskeletal disorders (5.8 per cent), and nervous system disorders (5.5 per cent) were the common AESIs in adults.

Menstrual abnormalities were noticed in 4.6 per cent of female participants. Ocular abnormalities and hypothyroidism were observed in 2.7 per cent and 0.6 per cent of participants Four deaths (three female individuals, one male individual) were reported in adults, the study added.

All four had diabetes, while hypertension in three, and a history of pre-vaccination COVID-19 was present in two of them.

Stroke was the main contributor in two deaths and one fatality was due to post-COVID-19 rhinocerebral mucormycosis, which supposedly disseminated after vaccination as reported by the caregivers.

The fourth death happened in a woman with multiple episodes of unconsciousness post-vaccination, the etiology of which remained unidentified till death. In the absence of a definite causality association, no conclusions can be drawn from these events.

With the majority of AESIs persisting for a significant period, extended surveillance of COVID-19-vaccinated individuals is warranted to understand the course and outcomes of late-onset AESIs, the study underlined.

Serious AESIs might not be uncommon and necessitate enhanced awareness and larger studies to understand the incidence of immunemediated phenomena post-COVID-19 vaccination .

Female individuals, adolescents with pre-vaccination COVID-19, those with co-morbidities, and those with post-vaccination typhoid had respectively 1.6, 2, 2.7, and 3.2 times higher odds of persistent AESIs.

Adults with co-morbidities had more than two times higher odds of AESIs and persistent AESIs, the study stated.

Adults receiving three doses and those receiving one dose of BBV152 were respectively at four and two times higher risk of AESIs compared with adults receiving two doses of the Covaxin, the study said.

Link: Over 30% Covaxin takers suffered from health issues after 1 year, claims BHU study

[Thad E Ginathom]

The non-medically trained were telephoned and asked what they had suffered from.

Medical names were attached to the results and published. Call in Dr Wakefield!

[Fuldagap]

Originally Posted by Thad E Ginathom

The non-medically trained were telephoned and asked what they had suffered from.

Medical names were attached to the results and published. Call in Dr Wakefield!

Are respondents supposed to be medically trained before any such study/research? ICMR was party to the research before distancing itself under possible duress.

Here is a glimpse:

Abstract
Background and Objective
Evidence on the long-term safety of COVID-19 vaccines is scarce. Here, in continuation of our previously published results on short-term safety, we provide data on the long-term safety of the BBV152 vaccine in adolescents and adults.

Methods
This was a prospective observational study conducted from January 2022 to August 2023. Adolescents and adults receiving the BBV152 vaccine were interviewed telephonically about long-term adverse events of special interest (AESIs) after 1 year of vaccination. Risk factors of AESIs and AESIs persistent for at least 1 month were identified.

Results
Out of 1024 individuals enrolled, 635 adolescents and 291 adults could be contacted during the 1-year follow-up. Viral upper respiratory tract infections were reported by 304 (47.9%) adolescents and 124 (42.6%) adults in this period. New-onset skin and subcutaneous disorders (10.5%), general disorders (10.2%), and nervous system disorders (4.7%) were the common AESIs in adolescents. General disorders (8.9%), musculoskeletal disorders (5.8%), and nervous system disorders (5.5%) were the common AESIs in adults. Menstrual abnormalities were noticed in 4.6% of female participants. Ocular abnormalities and hypothyroidism were observed in 2.7% and 0.6% of participants, respectively. Among serious AESIs (1%), stroke and Guillain–Barre syndrome were identified in 0.3% and 0.1% of participants, respectively. Among adolescents, female individuals, those with a history of allergy and post-vaccination typhoid were respectively at 1.6, 2.8, and 2.8 times higher risk of AESIs. The majority of the AESIs persisted at the 1-year follow-up. Female individuals, adolescents with pre-vaccination COVID-19, those with co-morbidities, and those with post-vaccination typhoid had respectively 1.6, 2, 2.7, and 3.2 times higher odds of persistent AESIs. Adults with co-morbidities had more than 2 times higher odds of AESIs and persistent AESIs.

Conclusions
The patterns of AESIs developing after BBV152 differed from those reported with other COVID-19 vaccines as well as between adolescents and adults. With the majority of AESIs persisting for a significant period, extended surveillance of COVID-19-vaccinated individuals is warranted to understand the course and outcomes of late-onset AESIs. Serious AESIs might not be uncommon and necessitate enhanced awareness and larger studies to understand the incidence of immune-mediated phenomena post-COVID-19 vaccination. The relationship of AESIs with sex, co-morbidities, pre-vaccination COVID-19, and non-COVID illnesses should be explored in future studies.

Springer Nature Link (The URL might not remain functional if the research gets retracted in future under pressure from powers).

Institute of Medical Sciences, Banaras Hindu University has the status of AIIMS by GOI.
Before this long term study, it had also published a short term study on the same subject.
What becomes politically incorrect is trolled anyways these days, whether it holds scientific value or not is not discussed.