My understanding of Corona. I have tried to simplify it:
Corona name comes from Latin for crown. The name refers to the characteristic appearance of surface projections creating an image reminiscent of a crown.
SARS-CoV-2 is the formal, scientific name of the actual virus, a not-quite-living thing that floats around and reproduces using living cells.
COVID-19 is the name for the disease that being infected with SARS-CoV-2 causes. Coughing, fever, and immune system malfunctioning are symptoms of COVID-19.
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The coronaviruses are a family of viruses of which SARS-CoV-2 is a strain. The family was classified in 1968.
In taxonomy, "strain" is the division below species. Coronavirus is not technically a species; it is a family (Coronaviridae). SARS, MERS, and COVID-19 are all in the Coronaviridae family, and also in the same genus (betacoronavirus), but after that they are separate. They are each different species within the betacoronavirus genus. There are also a coronavirus that are associated with the common cold, one being Corona Virus Strain 229E.
Coronaviruses (CoVs), within the order Nidovirales, are enveloped, single-strand, positive-sense RNA viruses with a large genome of approximately 30 kbp in length. CoV was cultured for the first time in human embryonic tracheal organ cultures by Tyrrell and Bynoe in 1965.
Among four genera of CoVs, beta-CoV includes five subgenus—embevovirus, sarbecovirus including severe acute respiratory syndrome (SARS)-CoV, merbecovirus including Middle East respiratory syndrome (MERS)-CoV, nobecovirus, and hibecovirus. Because CoVs can infect a variety of animals, SARS-CoV and MERS-CoV crossed the species barriers. Coronavirus virions are spherical with diameters of approximately 125 nm as depicted in recent studies by cryo-electron tomography and cryo-electron microscopy.
Coronavirus virus particles contain four main structural proteins. These are the spike (S), membrane (M), envelope (E), and nucleocapsid (N) proteins.
Coronaviruses contain a non-segmented, positive-sense RNA genome of ∼30 kb. The replicase gene encoding the nonstructural proteins (Nsps) occupies two-thirds of the genome, about 20 kb, as opposed to the structural and accessory proteins, which make up only about 10 kb of the viral genome. source:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4369385/ Conspiracy by China
Caixin global,
https://www.caixinglobal.com/2020-02...101521745.html, reported on the novel virus on 28th December 2019. The virus was sequenced in Chinese labs. A genomics company Vision Medicals, based in Huangpu district in Guangzhou, South China’s Guangdong province had sequenced most of the virus by 27th December, from fluid samples of a 65-year old deliveryman who was working at the seafood market where many of the first cases emerged. The patient was admitted to the Central Hospital of Wuhan on Dec. 18 with pneumonia and his condition quickly deteriorated. On Dec. 24, the doctors took fluid samples from his lungs and sent them to Vision Medicals for testing, according to Zhao Su, head of respiratory medicine at the hospital. The earliest results were returned on Dec. 27. The patient, who was transferred to Wuhan Jinyintang Hospital, later died. The company did, however, share the data with the Chinese Academy of Medical Sciences.
It showed an alarming similarity to the deadly SARS coronavirus that killed nearly 800 people in 2002-03. Samples of at least eight other patient from hospitals around Wuhan were sent to multiple Chinese genomics companies including BGI. The results all pointed to a dangerous SARS-like virus. All this happened days before China notified the World Health Organization (WHO) on Dec. 31 about the emergence of an unidentified infectious disease, 2 weeks before it shared the virus’s genome sequence with the world, and crucially, more than three weeks before Chinese authorities confirmed publicly that the virus was spreading between people.
On Dec. 30, Dr. Li Wenliang was one of several in Wuhan who sounded the first alarms and released initial evidence online. Li was punished for releasing the information and he died five weeks later, after contracting it from a patient.
Zhang Jixian, who heads the respiratory department at Hubei Xinhua Hospital, noticed on Dec. 26 that he had received a growing number of patients with symptoms of pneumonia from the neighboring seafood market. Following the reports, disease control authorities in Wuhan and Hubei on Dec. 30 issued an internal notice warning of the emergence of pneumonia patients with links to the seafood market and requiring hospitals to monitor similar cases. The notice, later leaked online, offered the first glimpse to the public of officials’ acknowledgement of the outbreak.
On Jan. 1, after several batches of genome sequence results had been returned to hospitals and submitted to health authorities, an employee of one genomics company received a phone call from an official at the Hubei Provincial Health Commission, ordering the company to stop testing samples from Wuhan related to the new disease and destroy all existing samples. Then on Jan. 3, China’s National Health Commission (NHC), the nation’s top health authority, ordered institutions not to publish any information related to the unknown disease, and ordered labs to transfer any samples they had to designated testing institutions, or to destroy them.
It was Jan. 9 when Chinese authorities finally announced that a novel coronavirus was behind Wuhan’s viral pneumonia outbreak. Even then, the transmissibility of the virus was downplayed, leaving the public unaware of the imminent danger.
Finally, on Jan. 20, Zhong Nanshan, a leading authority on respiratory health who came to national attention in his role fighting SARS, confirmed in a TV interview that the disease was spreading from person-to-person.
Two days later, Wuhan, a city of 11 million, was placed in lockdown.
Virus Isolation from the First Patient with SARS-CoV-2 in Korea.
[photo] (A)Vero cell cultures in negative control. (B) Cytopathic effects consisting of rounding and detachment of cells in Vero cell cultures 3 days after the first blind passage. (C, D) Transmission electron microscopy image of Vero cells infected with SARS-CoV-2. White arrow head denotes nuclear membrane, black arrow head extracellular virus particles, and thin black arrow cytoplasmic vesicle including virus components (C). Thick black arrow denotes magnified virus particles with crown-like spikes (D)
Source: Journal of Korean Medical Science. https://jkms.org/search.php?where=av...KMS&vmode=FULL
The isolated SARS-CoV-2 from the oropharyngeal sample obtained from the patient with the first laboratory-confirmed SARS-CoV-2 infection in Korea. Cytopathic effects of SARS-CoV-2 in the Vero cell cultures were confluent 3 days after the first blind passage of the sample. Coronavirus was confirmed with spherical particle having a fringe reminiscent of crown on transmission electron microscopy. Phylogenetic analyses of whole genome sequences showed that it clustered with other SARS-CoV-2 reported from Wuhan.
Frequently Asked Questions
COVID-19 spread
It is carried on respiratory droplets when we talk, sneeze, and cough and these can land on surfaces or in someone’s mouth or nose and this virus is really transmissible. It can spread easily from person to person even before a person develops symptoms. 6 feet is considered as the magic distance when it comes to respiratory droplets. Being within 6 feet of someone who is sick can get you or your personal space contaminated with COVID-19.
When droplets land on surfaces, we can pick them up with our hands and transfer them to our eyes, mouth, and nose when we touch our faces. This is why hand hygiene is so important. Respiratory secretions (like snot and sputum) are also infectious so cover your coughs and sneezes.
Symptoms of the virus
It typically causes flu-like symptoms. Some patients particularly the elderly and others with other chronic health conditions develop a severe form of pneumonia.
Patients develop symptoms like fever, muscle and body aches, cough, and sore throat about 5-6 days after infection. Some people won’t get as sick, but it’s still important not to be out and about, so as not to spread the disease. A minority of patients will get worse. This usually happens after 5-7 days of illness and these patients will have more shortness of breath and worsening cough. If this happens, it’s time to contact your doctor again or even go to an emergency room. Be sure to call first so they know you are coming.
Medical Care
About 80% of people who contract this new coronavirus will feel sick, but ultimately be just fine. It’s the 20% of COVID-19 patients who get really sick. A lot of these critically ill patients wind hospitalized for pneumonia like illnesses. They typically require critical care and ventilation. Some may need to stay on ventilators for weeks at a time. Depending on how many cases develop, providing that level of care for so many people over a number of weeks runs the risk of overwhelming the nation’s health care system pretty quickly. Practising social distancing help prevent this kind of “surge” in patients.
Risk of catching
Yes. It doesn’t appear anyone is naturally immune to this particular virus and there’s no reason to believe anybody has antibodies that would normally protect them.
Concern
The challenge with COVID-19 is that we probably can’t contain it and we don’t know if we’re really prepared as a country for a massive coronavirus epidemic. If we are lucky, it will slow down a bit over the summer but the next few months look like they are going to be pretty tough for all of us. We need to be as ready as we can for whatever comes our way and know that we will get through it eventually.
Protection
Take the preventive actions you do for the cold and flu. This includes avoiding close contact with people who are sick, not touching your eyes, nose and mouth, washing your hands thoroughly and frequently and cleaning and disinfecting objects and surfaces you come in contact with regularly.
Wearing a face mask to protect yourself from getting COVID-19 or other respiratory illnesses is not recommended. Those who have COVID-19 or are showing symptoms should wear a mask to protect others from getting the virus. Any healthcare worker taking care of someone infected with COVID-19 also should wear a mask.
Antibiotic or vaccination against the virus
There is no antibiotic (they are designed for bacterial infections, not viral ones) to treat COVID-19. Scientists are already working on a vaccine, but we don’t expect to have a good vaccine until spring of 2021 at the earliest. However, ongoing trials in China suggest that there are some existing antiviral drugs that may be helpful for the sickest patients. Drugs previously in development for SARS could be effective for COVID-19.
For now, doctors can only treat the symptoms, not the virus itself.
Etymology of other diseases Human Immunodeficiency Virus (HIV)
It originated in Congo in 1920s. Acquired Immune deficiency Syndrome (AIDS) is the name of the disease.
Tuberculosis
It originated from a group of smooth mycobacterium found in humans in East Africa.
Leprosy
The origins and worldwide distribution of leprosy is from East Africa or the Near East Africa along human migration routes. Phylogeography using single nucleotide polymorphism (SNP) analyses point to leprosy originating in Paleolithic times in Africa.
Ebola
It is named after a river in Zaire, now in Congo, in the 1970s.
Guinea Worm
It is named after the Gulf of Guinea, West Africa in the 17th century. It was known for centuries under various names.
West Nile virus
It is named after West Nile region of Uganda where it was first isolated in the 1930s.
Lassa fever
It is named after a town in Nigeria where it was identified in the 1960s.
Syphilis
The origin of syphilis is disputed. First written records of an outbreak of syphilis in Europe occurred in 1494 or 1495 in Naples, Italy. Some sort of non venereal has been found to cause syphilis-like lesions in Guyanese indigenous people, so it is not clear.
Russian Flu
The USSR was the first to report the outbreak in 1977 but the strain was actually isolated in China. It was a "benign" pandemic. The virus was not novel.
Hepatitis A
It originated in the former Soviet Union during the time they were establishing world's first centralized national blood transfusion and storage service during 1920- 1950.
Hepatitis B
It started in North Africa and Middle East. The virus then spread to the rest of the world.
Asian Flu
It originated in China in early 1956. It is a category 2 flu pandemic outbreak of avian influenza. H2N2.
Hong Kong Flu
The Hong Kong Flu was a 1968-69 pandemic caused by a strain of H3N2 descended from H2N2.
Avian Flu
The virus was first detected in geese in China in 1996. It was first detected in humans in 1997 in Hong Kong. H5N5.
Middle East respiratory syndrome (MERS)
First found in Saudi Arabia in 2012-13. It is a Corona Virus outbreak.
German Measles
Rubella, named not for its origin, but because German physicians were first to identify it in the 19th century.
Omsk Hemorrhagic Fever
It emerged in Omsk, Russia in the 1940s.
Marburg virus
It is named after a town in Germany where an outbreak occurred in a lab in the 1960s. It is an Ebola-type hemorrhagic virus.
St. Louis encephalitis
It is named after a town, St. Louis, in Missouri, USA, where an epidemic emerged in the 1930s.
La Crosse Encephalitis
It is named after city, La Crosse, in Wisconsin, USA, in the 1960s.
Rocky Mountain spotted fever
It is named after the Rocky Mountains, USA. First outbreak was in early 1800s.
Lyme Disease
It is named after Old Lyme, a town in Connecticut, USA. First outbreak started in 1970s.
Hantavirus
It is named after the Hantan River in South Korea, where it was isolated in the 1970s.
Ross River Fever
It is named after a river, Ross River, in Queensland, Australia. First outbreak in in 1920s.
Zika
It was identified in Uganda in 1947 in monkeys. It was later identified in humans in 1952.
Spanish flu
It originated in China in 1917. It started either in Étaples, France or in Kansas, USA. It is named so because it was reported first by Spain during 1918.
Dysentery
Shigella dysenteriae, the bacterium that causes dysentery, originated in Europe and was spread to the rest of the world by emigrants and colonizers.
Yellow Fever
It originated in East or Central Africa. Slave trade by U.S.A in 1700s helped it to spread all over.
Severe acute respiratory syndrome (SARS)
It originated in Guangdong, China. May 2003.
Nipah
It originated in Sungai Nipah, Malaysia in 1998.
The Black Death by bubonic plague
It originated from China and spread to Europe, starting from 1334.
Meningitis
The first recorded major outbreak occurred in Geneva, Switzerland in 1805.
Japanese encephalitis
It emerged in Japan in the 1870s. Oldest lineage is from Indonesia-Malaysia region in the mid 1500s.